Tag: Total Synthesis
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Troc Protecting group Mechanism & (De)Protection
The Troc protecting group protects amines and alcohols from acid, base and electrophiles. It is deprotected by reduction. Troc (also 2,2,2-trichloroethoxycarbonyl) is a really exotic but versatile protecting group. Let’s learn why. What is the Troc Protecting Group? Troc (2,2,2-trichloroethoxycarbonyl) can convert amines or alcohols into stable carbamate or carbonate derivatives. This leads to a…
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Total Synthesis Of Cocaine (Wilstätter)
Did you know that while Coca Cola was getting consumers casually coked up in the late 19th century, chemistry titans were fighting an epic battle around cocaine synthesis? With a Nobel Prize on the line, the stakes were high, cocaine’s structural complexity was high… and everybody else was high too. Keep reading to learn more…
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What is Total Synthesis? The Basics Explained
This post explains the question: What is total synthesis? If you read this, you might be forced to study organic chemistry 🙁 or are already interested in total synthesis. In any case, this brief commentary will explain the concept very simply. For advanced content, check out this page or my videos. Imagine you’re a pastry…